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Avoiding pre-analytic errors
How to avoid errors when collecting capillary blood samples
- Before puncture1, clean the site with alcohol and let it air dry to prevent hemolysis of the sample; do not wipe it dry
- After puncture, use clean gauze to wipe away the first drop of blood to prevent diluting the sample with interstitial fluid1,2
- Touch the collection device to the second drop of blood and allow the blood to flow into the collection tube via capillary action, using a gentle squeeze and release technique to ensure steady blood flow and prevent hemolysis or unwanted clots in the sample2
- Do not squeeze the finger excessively or use a scraping or scooping motion when collecting the blood to help prevent hemolysis and dilution with interstitial fluid1,2
EXPERT TIP:Optimizing collection technique minimizes the risk of inaccurate results.
These materials were developed in consultation with key opinion leaders and in accordance with global guidelines, but users should apply their own professional judgment when using any technique or method described in these materials and also consider all relevant national, regional, and institutional guidelines and regulations.
References
1. WHO guidelines on drawing blood: best practices in phlebotomy. World Health Organisation; 2010.
2. Clinical and Laboratory Standards Institute (CLSI) document GP42-A6 (formerly H04-A6): Procedures and Devices for the Collection of Diagnostic Capillary Blood Specimens; Approved Standard – Sixth Edition. Clinical and Laboratory Standards Institute; Wayne, Pennsylvania, USA: 2008..